Overcoming immune escape in WT1 peptide vaccination for malignant glioma

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462257
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Research Institute, Osaka Medical Center for Maternal and Child Health (2015-2016); Osaka University (2013)
• Principal Investigator: Chiba Yasuyoshi 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 脳神経外科・医長 (90533795)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: WT1 / peptide vaccine / immunotherapy / glioma / GBM / HLA class 1 / PD-1 / PD-L1

Outline of Final Research Achievements

In this work, we tried to elucidate the mechanism of immune escape of tumor cells in WT1 peptide vaccination from human specimens and animal experiments. In a study using a human specimen, it was suggested that when WT1 peptide vaccination is administered, tumor cells decrease the expression of WT1 and HLA class 1 and secrete TGFβ, thereby escape attack by immunity. In the animal experiments, it was found that in the WT1 peptide vaccine group, killer T cells infiltrate into the tumor to exert antitumor effect and the survival time was prolonged, and methionine PET is excellent as a judgment of its effect.

Free Research Field

脳腫瘍学