Analyzing the possible involvement of anti-Müllerian hormon and anti-Müllerian hormon receptor II single nucleotide polymorphism in infertility

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462581
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka Medical College
• Principal Investigator: Yamashita Yoshiki 大阪医科大学, 医学部, 非常勤講師 (50268207)
• Co-Investigator(Kenkyū-buntansha): Ohmichi Masahide 大阪医科大学, 医学部, 教授 (10283764) ; Terai Yoshito 大阪医科大学, 医学部, 講師 (90278531) ; Tanabe Akiko 大阪医科大学, 医学部, 助教 (70454543) ; Hayashi Atushi 大阪医科大学, 医学部, 助教 (80411338) ; Hayashi Masami 大阪医科大学, 医学部, 助教 (00551748)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ＡＭＨ / AMH: 146 T>G / -482 A>G / IVS1+149 T>A / IVS5-6 C>T / ＡＭＨＲ

Outline of Final Research Achievements

In this study, -482 A>G homozygote mutation was associated with ISV5-6 C>T homozygote mutation, and the oocyte retrieval rate of -482 A>G homozygote mutation was statistically lower than in the control group and in other SNPs, despite the result that total dose of hMG/FSH for oocyte retrieval in -482A>G homozygote mutation cases showed no statistical difference compared with the wild type. These results suggest that -482 A>G homozygote mutation could cause poor follicular development. In the normal pregnancy group, all cases of -482 A>G homozygote mutation were associated with ISV5-6 and showed poor obstetric outcome. In conclusion, additional replication and functional studies are necessary to secure definite conclusions as to the effect of AMHRII -482 A>G polymorphism on infertility and obstetric outcome. However, this study revealed the possible involvement of AMHRII -482 A>G polymorphism on the malfunction of follicular development in Japanese women.

Free Research Field

生殖医学