2015 Fiscal Year Final Research Report
Regeneration of ocular surface fibrosis by human mesenchymal stem cell transplantation
| Project/Area Number |
25462759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
YAMANAKA Osamu 和歌山県立医科大学, 医学部, 博士研究員 (50254545)
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| Co-Investigator(Kenkyū-buntansha) |
SAIKA Shizuya 和歌山県立医大, 医学部, 教授 (40254544)
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| Research Collaborator |
KAO Winston シンシナティ大学, 医学部, 教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 創傷治癒 / 幹細胞 / 線維化 |
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| Outline of Final Research Achievements |
We investigated the biological functions of human umbilical mesenchymal stem cells (hUMSC). hUMSC suppressed scar formation of alkali burn mouse model. Our findings showed that hUMSC mediated the activation of growth factors or cytokines such as TGFβ andTNFα to suppress fibrosis. We suggested that TNFα and βcatenin deeply associated the process of scar formation. hUMSC could be a novel alternative for treating ocular surface fibrosis.
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| Free Research Field |
眼創傷治癒
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