2015 Fiscal Year Final Research Report
The effectiveness of erythropoietin for the pulmonary hypertension with the congenital diaphragmatic hernia patients
| Project/Area Number |
25462769
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUMOTO Kouji 筑波大学, 医学医療系, 教授 (20343329)
UESUGI Toru 筑波大学, 医学医療系, 講師 (30380421)
GOTOH Chikashi 筑波大学, 医学医療系, 講師 (80598889)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 先天性横隔膜ヘルニア / ラットモデル / 肺高血圧 / RhoA / エリスロポエチン |
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| Outline of Final Research Achievements |
Our results using nitrofen-induced congenital diaphragmatic hernia (CDH) provide evidence that the RhoA/Rho-kinase-mediated pathway is involved in the pathogenesis of PH in the nitrofen-induced CDH rat model. Our data also suggest that the fasudil, a Rho-kinase inhibitor, could represent a therapeutic option for the treatment of PH in CDH. We also found the suppressed EPO synthesis in the CDH fetus, which may contribute to the pathogenesis of lung hypoplasia and modification of pulmonary vasculature in the CDH rat model.
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| Free Research Field |
小児外科
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