Analysis of the expression of drug resistance-related genes in tumor blood vessels

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SUZUKI Yuko 北海道大学, 遺伝子病制御研究所, 学術研究員 (90646118)
• Co-Investigator(Kenkyū-buntansha): OHGA Noritaka 北海道大学, 大学院歯学研究科, 助教 (40548202) ; AKIYAMA Kosuke 北海道大学, 遺伝子病制御研究所, 客員研究員 (10609100) ; MAISHI Nako 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腫瘍血管 / 薬剤抵抗性 / トランスポーター

Outline of Final Research Achievements

We have reported that drug resistance-related gene, P-glycoprotein (P-gp) is upregulated in tumor endothelial cells (TECs). In this study, we examined the involvement of P-gp expression of TEC in cancer refractory. When TECs were treated with both paclitaxel and P-gp inhibitor, TEC proliferation was inhibited compared to paclitaxel alone group. Combination treatment with paclitaxel and P-gp inhibitor abrogated TEC resistance in mouse tumor model. These results suggested that inhibiting P-gp in TECs may be a good strategy for cancer therapy.

Free Research Field

腫瘍血管新生