Study of the effects of serine proteases on the cariogenicity of Streptococcus mutans

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462962
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: OZAKI Kazumi 徳島大学, 大学院医歯薬学研究部, 教授 (90214121)
• Co-Investigator(Kenkyū-buntansha): YUMOTO Hiromichi 徳島大学, 病院, 講師 (60284303) ; HOSOKAWA Yoshitaka 徳島大学, 大学院医歯薬学研究部, 助教 (90346601)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: バイオフィルム / クオラムセンシング / オートインデューサー

Outline of Final Research Achievements

The aim of this study was to evaluate the effect of the enzymes, which digest autoinducers, on the cariogenicity of Streptococcus mutans. Trypsin and rHtrA were tended to inhibit bacterial growth and the adherence of S.mutans to a glass test tube, furthermore, suppress biosynthesis of intra/extra-cellular polysaccharide in comparison with negative control. These results suggested that these enzymes will be able to exhibit antibacterial activities and inhibit biofilm formation by S.mutans.

Free Research Field

歯科保存学