2015 Fiscal Year Final Research Report
Analysis of expression pattern and function of micro-RNA in craniosynostosis
| Project/Area Number |
25463168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOBAYASHI YUKIHO 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (20596233)
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| Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Keiji 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20262206)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 頭蓋冠縫合部早期癒合症 / miRNA |
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| Outline of Final Research Achievements |
We analyzed the expression pattern of miRNA in the calvarial sutures of Apert syndrome model mice (Ap mice) and the control mice (Ct mice). Ap mice showed higher expression of 19 kinds of miRNA and lower 5 kinds of miRNA significantly. Additionally, mmu-miR-182-5p and mmu-miR-206-3p significantly highly expressed in Ap mice by real-time PCR.
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| Free Research Field |
歯科矯正学
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