A novel mechanism of posttransplant female infertiliy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670443
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Hokkaido University
• Principal Investigator: TESHIMA TAKANORI 北海道大学, 医学(系)研究科(研究院), 教授 (40284096)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 造血幹細胞移植 / GVHD / 卵巣 / 不妊 / 免疫抑制剤

Outline of Final Research Achievements

Infertility associated with ovarian failure is a serious late complication for female survivors of allogeneic hematopoietic stem cell transplantation (allo-SCT). We have addressed whether GVHD could impact female fertility in murine models of allo-SCT.　Our results demonstrate for the first time that GVHD induces infertility by targeting the granulosa cells in the ovaries and GVHD prevention could preserve ovarian functions. These results have important clinical implications in young female transplant recipients with nonmalignant diseases, where minimally toxic chemotherapies prior to SCT and conditioning regimen were used.

Free Research Field

血液内科学