Genetic screening of Japanese macaque aiming at discovery of primate models for psychiatric disorders

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670516
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: OZAKI Norio 名古屋大学, 医学(系)研究科(研究院), 教授 (40281480)
• Co-Investigator(Renkei-kenkyūsha): IMAI Hiroo 京都大学, 霊長類研究所, 准教授 (60314176)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ニホンザル / CNV

Outline of Final Research Achievements

Recent genomic studies of psychiatric disorders have identified rare copy number variants (CNVs) with large effect size. In order to discover primate model for psychiatric disorders, we have performed genome-wide CNV screening in Japanese macaque. As a result, we detected CNVs overlapping neurodevelopmental genes including GRM5, NGF, BDNF, and ADORA2A. In particular, a duplication of ADORA2A region was previously implicated in psychiatric and neurodevelopmental disorders. Abnormal behaviors were not identified in one Japanese macaque with ADORA2A duplication, and a detailed phenotype analysis will be necessary in the future. In conclusion, we discovered candidates of primate model for psychiatric disorders, confirming the usefulness of CNV analyses for Japanese macaque.

Free Research Field

精神医学、ゲノム医学