Development of alpha-synuclein selective PET probe

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670524
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: OKAMURA Nobuyuki 東北大学, 医学(系)研究科(研究院), 准教授 (40361076)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: αシヌクレイン / パーキンソン病 / PET / バイオマーカー

Outline of Final Research Achievements

Non-invasive detection of α-synuclein deposits would be useful to diagnose Parkinson's diseases accurately as well as to track disease progression. In order to develop a sensitive and selective α-synuclein PET probe, we screened around 160 compounds and found several compounds which show high binding affinity to α-synuclein fibrils. Especially, compound C binds with high affinity to α-synuclein fibrils. Autoradiographic analyses showed that this compound preferentially bound to Lewy bodies in the midbrain sections from patients with Parkinson’s disease. Intravenous administration of this compound further demonstrated sufficient blood-brain barrier permeability in mice. These findings suggest that [18F]compound C is a promising candidate for PETα-synuclein imaging probes.

Free Research Field

薬理学