2013 Fiscal Year Final Research Report
Mechanism of transcriptional regulation from arachnoid cells to endothelial cells
| Project/Area Number |
25670619
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
WADA Youichiro 東京大学, アイソトープ総合センター, 教授 (10322033)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | 脳血管障害 / トランスクリプトーム / エピゲノム |
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| Research Abstract |
It is not fully elucidated the role of arachnoid cells in the course of subarachnoid hemorrhage. It was found that arachnoid cells could contribute to the recovery from cerebrovascular diseases. To elucidate the transcriptional regulation mechanism of arachnoid cells, we performed comprehensive transcriptional analysis followed by epigenetic analysis. We found some of histone modifications were dynamically changed, suggesting the importance of chromatin dynamics of arachnoid cells. Based on the outcome of this project, further study is now ongoing to confirm and validate the significance of these findings.
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[Journal Article] Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells2014
Author(s)
Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y.
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Journal Title
PLoS One
Volume: 9(5)
Pages: e96005
DOI
Peer Reviewed
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[Journal Article] Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements2014
Author(s)
Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro JI, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, Ruan Y, Kodama T, Wada Y
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Journal Title
Genome Biol.
Volume: 15(4)[Epub ahead of print]
Pages: R63
Peer Reviewed
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