Bcl-2 family protein Mcl-1 regulates osteoclastogenesis by the anti-apoptotic function

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670635
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: OSHIMA Yasushi 東京大学, 医学部附属病院, 講師 (50570016)
• Co-Investigator(Kenkyū-buntansha): TAKEYUKI Tanaka 東京大学, 医学部附属病院, 助教 (00583121)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 破骨細胞

Outline of Final Research Achievements

Osteoclast is a multinuclear, bone eating cell. The metabolism of bone is maintained by a subtle balance of bone formation and resorption. The collapse of this bone metabolism causes osteoporosis, arthritis and then joint destruction. It's known that Bcl-2 family which has a function of mitochondria process in apoptosis makes essential effect on osteoclast. We examined the unknown function of Mcl-1 in osteoclast which is one of Bcl-2 family protein. We elucidated that Mcl-1 has functions of positive effect on survival rate of osteoclast and negative effect on the resorption.

Free Research Field

骨代謝学