Application of boron carbide particles to boron neutron capture therapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670857
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: YURA YOSHIAKI 大阪大学, 歯学研究科(研究院), 教授 (00136277)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔扁平上皮癌 / 中性子 / ホウ素化合物 / 炭化ホウ素球 / 超音波照射 / 溶媒

Outline of Final Research Achievements

Boronophenylalanine (BPA)is a major boron compound used in boron neutron capture therapy (BNCT)for cancer patients. Boron-rich boron carbide (B4C) nanoparticles are novel compounds containing a large number of born molecules. The tumor volume was smaller in B4C-mediated BNCT group than in neutron group. Purebright MB was found to solubilize B4C particles. This suggests that B4C particles injected intratumorally act as boron compounds for BNCT.

Free Research Field

口腔外科学