2014 Fiscal Year Final Research Report
Effect of high-energy visible light on animal cells.
| Project/Area Number |
25740018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Tamagawa University |
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Principal Investigator |
SATO Kazuomi 玉川大学, 農学部, 准教授 (10554991)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アポトーシス / 細胞死 / 可視光線 / 青色光 / ミトコンドリア / メラニン生成 |
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| Outline of Final Research Achievements |
The aim of the present work was to clarify the mechanism of cell death induced by visible light. Blue light induced mitochondrial membrane potential depolarization subsequent to elevation of intracellular superoxide production. Moreover, blue light induced cell surface exposure of phosphatidylserine. Mitochondrial membrane potential is an indicator of mitochondria-dependent apoptosis. Thus, blue light causes mitochondrial dysfunction and subsequent apoptosis.
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| Free Research Field |
分子細胞生物学
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