2014 Fiscal Year Final Research Report
Evaluation of usability of IL1RAPL1 knockout mice as an animal model of neuropsychiatric disorders
| Project/Area Number |
25830048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 行動解析 / シナプスオーガナイザー / 知的障害 / 自閉症 |
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| Outline of Final Research Achievements |
The spine density of basal dendrites of cortical layer 2/3 and hippocampal CA1 pyramidal neurons was significantly reduced in IL1RAPL1 knockout mice. We found that the spatial reference and working memories and remote fear memory were impaired in IL1RAPL1 knockout mice. These results suggest that IL1RAPL1 knockout mice are an animal model of intellectual disability. IL1RAPL1 knockout mice also exhibited slightly reduced behavioural flexibility and increased sociability. In addition, IL1RAPL1 knockout mice exhibited high locomotor activity and reduced open-space and height anxiety-like behaviours.
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| Free Research Field |
神経科学
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