2014 Fiscal Year Final Research Report
Differentiation and transplantation of insulin-secreting cells generated from mouse-derived iPS cells.
| Project/Area Number |
25830064
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | マウスES/iPS細胞 / インスリン産生細胞 |
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| Outline of Final Research Achievements |
Islet transplantation has been suggested to be a promising treatment for type 1 and type 2 diabetes. iPS cells have potential cure for diabetes using a cellular therapy to ameliorate symptoms associated with both reduced insulin secretion and insulin sensitivity. Therefore, highly efficient differentiation of iPS cells into insulin-secreting cells will enhance the potential for patient specific cell transplantation therapy in diabetes. Here, we demonstrate that mouse-derived iPS cells can be differentiated into insulin-secreting cells in vitro and that they respond to glucose stimulation under physiological conditions. The hyperglycemic phenotype in model mice was improved by transplantation of the insulin-secreting cells.
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| Free Research Field |
実験動物学
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