Analysis of soluble and labile chemical species changes using time dependent cold-spray ionization mass spectrometry

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860033
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Tokushima Bunri University
• Principal Investigator: OHARA Kazuaki 徳島文理大学, 薬学部, 助教 (60581775)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: コールドスプレーイオン化 / ソフトイオン化 / 配位オリゴマー / 錯形成反応追跡 / 帰属

Outline of Final Research Achievements

Cold-spray ionization mass spectrometry (CSI-MS) is a soft ionization method to ionize chemical species constructed with weak interaction without fragmentation. In this study, several coordination species were detected by CSI-MS in complexation. Two different ligands solutions were mixed at different ratios and metal solution was added to their ligands solutions, and then coordination complexes were synthesized. After crystallization by adding a poor solvent to the solutions, two different crystals were obtained at two different ratios．This fact indicated that ion peaks change of CSI-MS was related to a crystalline structure change. In addition, it was found that component-composition analysis could effectively assign the ion peaks detected in soft ionization.

Free Research Field

分析化学，錯体化学