Enhancement of anti-tumor activity of hybrid peptide by complexation with high molecular weight biodegradable polymers

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860113
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: GAOWA Arong 京都大学, 医学(系)研究科(研究院), 研究員 (50643805)
• Research Collaborator: TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371) ; HARADA Hiroshi 京都大学, 大学院医学研究科, 特定准教授 (80362531)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 癌 / DDS / ペプチド / 動態

Outline of Final Research Achievements

To improve the pharmacokinetics and anti-tumor activity of EGFR2R-lytic hybrid peptide after intravenous injection, we prepared a high molecular weight biodegradable polymer as delivery system for controlled release of the peptide. In vitro release studies confirmed that the hybrid peptide was released from the complex in a sustained manner. In vivo release studies indicated that the anti-tumor activity of the complex was more effective than that of peptide treatment alone, and high tumor accumulation of the peptide was observed in the mice treated with the complex. Furthermore, the plasma area under the concentration curve (AUC) and half-life (T1/2) values of the complex were higher than those of the peptide treatment alone, respectively.

Free Research Field

医歯薬学