The roles of (pro)renin receptor in cerebral, cardiac and renal diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860156
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Tohoku University
• Principal Investigator: HIROSE Takuo 東北大学, 医学(系)研究科(研究院), 助教 (20599302)
• Research Collaborator: IMAI Yutaka 東北大学, 大学院薬学研究科, 教授 (40133946) ; TOTSUNE Kazuhito 東北大学, 大学院薬学研究科, 客員教授 (10217515) ; TAKAHASHI Kazuhiro 東北大学, 大学院医学系研究科, 教授 (80241628) ; MORI Takefumi 東北大学, 大学院医学系研究科, 准教授 (40375001) ; GENEVIEVE Nguyen College de France, Center for Interdisciplinary Research in Biology, Director
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: (プロ)レニン受容体 / レニン・アンジオテンシン系 / 生理活性物質 / 発生 / 組織障害

Outline of Final Research Achievements

The aim of this study is to clarify the roles of (pro)renin receptor in cerebral, cardiac and renal diseases. We have generated muntant mice carrying a conditional deletion in brain cortex. The mutant mice displayed a flattened forehead corresponding with a lack of nearly their entire cortex. (pro)renin receptor regulate lysosomal pH via V-ATPase membrane assembly and relate to autophagy. We also showed that plasma concentration of soluble (pro)renin receptor is independent of plasma renin, prorenin and aldosterone concentrations and that plasma (pro)renin receptor concentration is increased in the patients of congestive heart failure, chronic renal failure and pancreatic cancer.

Free Research Field

分子生物学