2014 Fiscal Year Final Research Report
A new treatment strategy for diarrhea and constipation via intestinal aquaporin
| Project/Area Number |
25860195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アクアポリン / 下痢 / 便秘 / モルヒネ / センノシドA / 大腸 |
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| Outline of Final Research Achievements |
Aquaporin (AQP), which are water channels, plays an important role in the water transport in the body. In this study, we investigated the role of colon AQP3 in the development of diarrhea and constipation. It was clarified that sennoside A induced the diarrhea accompanied by the decrease of the colon AQP3. In addition, it was revealed that morphine induced the constipation accompanied by the increase of the colon AQP3. Therefore, new laxatives and antidiarrheals targeting intestinal AQP3 may be developed in the future.
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| Free Research Field |
医療薬学
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