Significance of adrenomedullin in cardiac remodeling through the regulation of lymphangiogenesis and inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: MINAMI Takeya 京都大学, 医学(系)研究科(研究院), 研究員 (00647208)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 循環器 / 遺伝子 / 液性因子 / リモデリング

Outline of Final Research Achievements

In this study, we examined the role of adrenomedullin (ADM) in pathological cardiac remodeling. We succeeded to create cardiac-specific ADM conditional knock out mice (ADM ccKO) and found that their cardiac structure and function did not significantly differ from control mice in both basal- and pressure overloaded-conditions. We also created cardiac fibroblast ADM knockout mice (ADM fcKO), whose cardiac function and structure were not significantly different from those of control mice. These results suggest that ADM produced by other cells than either cardiac myocytes or cardiac fibroblasts can compensate for the loss of ADM in cardiac myocytes or fibroblasts, respectively.

Free Research Field

循環器内科学