2014 Fiscal Year Final Research Report
The glycosphingolipid-mediated recognition of mycobacteria by human phagocytes
| Project/Area Number |
25860831
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 病原性抗酸菌 / リポアラビノマンナン / 好中球 / ラクトシルセラミド / 貪食 / 食胞成熟阻害 |
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| Outline of Final Research Achievements |
Pathogenic mycobacteria such as Mycobacterium tuberculosis cause phagosomal maturation (phagosome-lysosome fusion) arrest. In this study, we aimed to elucidate the mechanism of glycosphingolipid-mediated mycobacterial recognition. Our results showed that mycobacterial LAM bound to lactosylceramide (LacCer), and affected LacCer-mediated phagosomal maturation in human neutrophils. These results provide new insights into how pathogenic mycobacteria inhibit phagosome-lysosome fusion.
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| Free Research Field |
生化学、糖鎖生物学、感染免疫学
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