2014 Fiscal Year Final Research Report
Mechanism of inhibition of Muller cell dedifferentiation and proliferation
| Project/Area Number |
25861656
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ミュラー細胞 / 網膜 |
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| Outline of Final Research Achievements |
We analyzed the mechanism of Muller cell dedifferentiation and proliferation in rodent models of photoreceptor damage. We examined expression Notch1 and Notch2 at mRNA and protein levels after photoreceptor damage. We found that expression of Notch1 and Notch2 mRNA are highly induced. Notch2 protein expression is also changes, accordingly. In contrast, we didn't detect Notch1 protein. We found that expression of Notch1 protein leveles increse with proteasome inhibitor. Our findings reveal that the degradation of Notch protein by ubiquitin-proteasome system may be one of the mechanisms that limit retinal regeneration in mammals.
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| Free Research Field |
医歯薬学
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