2014 Fiscal Year Final Research Report
Reactionary dentin formation by alkali-sensing TRP channels
| Project/Area Number |
25861762
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
KIMURA Maki 東京歯科大学, 歯学部, その他 (90582346)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 象牙芽細胞 / アルカリ刺激 |
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| Outline of Final Research Achievements |
In odontoblasts, alkaline stimuli activate the intracellular Ca2+ signaling pathway via Ca2+ influx from the extracellular space and intracellular Ca2+ release. These high-pH induced Ca2+ mobilizations showed dependence on extracellular Ca2+; TRPA1 channels mediated the Ca2+ influx. The plasma membrane and intracellular high-pH-sensing mechanisms in odontoblasts may play an important role in cellular functions during dentinogenesis induced by calcium hydroxide.
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| Free Research Field |
口腔生理学
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