Neural mechanism of cost-benefit based controlling motivation

2017 Fiscal Year Final Research Report

• Project/Area Number: 26282221
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Minamimoto Takafumi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, チームリーダー(定常) (50506813)
• Co-Investigator(Renkei-kenkyūsha): HORI Yukiko 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 研究員 (30433246) ; NAGAI Yuji 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 研究員 (20415409)
• Research Collaborator: KIKUCHI Erika
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 意思決定 / サル / 遅延報酬割引 / DREADDs

Outline of Final Research Achievements

In this research we obtained three findings: 1) the dorsal caudate that receives innervation from the dorsolateral prefrontal cortex, is involved in controlling motivation based on temporal-discounting; 2) the rostromedial caudate that receives innervation mainly from the anterior cingulate cortex and orbitofrontal cortex, is involved in controlling motivation based on reward value; 3) the nucleus accumbens, especially its anterior portion, is involved in controlling motivation based on cost-benefit balance.

Free Research Field

神経科学