Development of new diagnostic method for dementia by fusion of PET and NIRS

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293133
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Tohoku University
• Principal Investigator: WATABE HIROSHI 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (40280820)
• Co-Investigator(Kenkyū-buntansha): 田代 学 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
• Co-Investigator(Renkei-kenkyūsha): KUBO Hitoshi 福島県立医科大学, 先端臨床研究センター, 教授 (00325292) ; WATANUKI Seiichi 東北大学, サイクロトロン・ラジオアイソトープセンター, 助手 (30210967) ; MIYAKE Masayasu 東北大学, サイクロトロン・ラジオアイソトープセンター, 助手 (30210967) ; SHIDAHARA Miho 東北大学, 医学系研究科, 講師 (20443070)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 医学物理 / PET / NIRS

Outline of Final Research Achievements

In order to dramatically improve the diagnostic ability of Alzheimer's disease, this study aims to develop a new diagnostic method for PET amyloid β imaging agent and construct a fusion system of PET image and NIRS data. Based on the chemical form of the agent, we could predicted PET data for sevral PET amyloid pharmaceuticals, and derived CUI (clinical usefulness index) to evaluate its diagnostic ability. We also developed a PET/NIRS fusion system using an optical tracking device and evaluated its effectiveness by clinical experiments. As a result, PET and NIRS data were displayed in the same coordinate system in the brain, and analysis of both modalities could be merged.

Free Research Field

放射線医工学