Molecular mechanisms underlying heart failure development and progression caused by alteration of cardiac remodeling

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293190
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kumamoto University
• Principal Investigator: Oike Yuichi 熊本大学, 大学院生命科学研究部(医), 教授 (90312321)
• Co-Investigator(Renkei-kenkyūsha): MINAMINO Tohru 新潟大学, 医歯学系, 教授 (90328063)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心不全 / ANGPTL2 / 心エネルギー代謝

Outline of Final Research Achievements

Heart failure prohibits living people from living a healthy life. The number of patients with heart failure is increasing globally as we become an aging society. Thus, clarification of the mechanisms underlying heart failure development and progression is crucial to develop a useful strategy for treatment. In this study, we showed that angiopoietin-like protein 2 (ANGPTL2) expression is increased in pathologically stressed heart and that elevated cardiac ANGPTL2 impairs Ca2+ handling and energy metabolism in cardiomyocytes, thereby accelerating cardiac dysfunction. Moreover, we demonstrated that suppression of ANGPTL2 induction in cardyomyocytes using adeno-associated virus vector harboring Angptl2 shRNA could be a novel therapeutic strategy against cardiac dysfunction.

Free Research Field

循環器病態学／分子遺伝学