Degranulation from mast cell in the onset of allergic rhinitis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293368
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of Fukui
• Principal Investigator: Fujieda Shigeharu 福井大学, 学術研究院医学系部門, 教授 (30238539)
• Co-Investigator(Kenkyū-buntansha): 徳永 貴広 福井大学, 医学部附属病院, 特命助教 (10464075) ; 野口 恵美子 筑波大学, 医学医療系, 教授 (40344882) ; 高林 哲司 福井大学, 医学部附属病院, 講師 (70397272)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: スギ花粉症 / HLA-DR / Apolipoprotein A4 / Dectin-1 / TSLP / IL-33 / C3a / C5a

Outline of Final Research Achievements

HLA-DPB1*02:01 and HLA-DPB1*02:02 had a protective tendency and DPB1*05:01 had a susceptible tendency for sensitization of Japanese cedar pollen. Apo A4, which is induced by sublingual immunotherapy, inhibited sneezing, nasal itching and nasal obstruction. Dectin-1 is a critical factor in the tyrosine phosphorylation in mast cells. TSLP and IL-33 are important factors in production of IgE, but not release histamine from mast cells. Serum levels of C3a, C5a and IL-A were associated with symptom scores and increased by sublingual immunotherapy.

Free Research Field

耳鼻咽喉科