Prospective cohort study on the relationship between oral health and cardiovascular disease in general urban population

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293411
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Niigata University
• Principal Investigator: Ono Takahiro 新潟大学, 医歯学系, 教授 (30204241)
• Co-Investigator(Kenkyū-buntansha): 山本 雅章 大阪大学, 歯学研究科(研究院), 助教 (00508682) ; 小島 美樹 大阪大学, 歯学研究科(研究院), 助教 (20263303) ; 小久保 喜弘 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217) ; 関根 伸一 大阪大学, 歯学部附属病院, 助教 (70506344) ; 高阪 貴之 大阪大学, 歯学部附属病院, 医員 (40755360)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口腔健康 / 動脈硬化性疾患 / メタボリックシンドローム / 咀嚼能力 / 歯周病

Outline of Final Research Achievements

Basic health check-up and oral examination were performed in randomly selected urban Japanese population aged 50-70 years for investigating the relationship between oral health and the risk of cardiovascular disease. Significant relationship between periodontal disease and the prevalence of metabolic syndrome (MetS) was shown with the odds ratio having periodontal disease of 2.27 in men and 1.76 in women with 4 or more MetS components comparing with no components. On the other hands, the group with declined masticatory performance had higher odds ratio having MetS comparing with the highest masticatory performance group, and such tendency was prominent in 70's years subjects. These results suggested the possibility that the prevention of periodontal disease and decline of masticatory ability contributed to the prevention of cardiovascular disease.

Free Research Field

歯科補綴学