2016 Fiscal Year Final Research Report
Study of mechanism of carcinogenesis by 1,2-dichloropropane using animal experiment model
| Project/Area Number |
26340042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 1,2-ジクロロプロパン / 動物実験モデル / 発がん性 / 二段階発がん |
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| Outline of Final Research Achievements |
In this study, 1,2-dichloropropane (1,2-DCP) and toxicity were investigated using an animal experiment model. As a result, bile duct carcinogenicity was not observed in mouse, rat and hamster in animal test with single exposure of 1,2-DCP and DCM. However, co-exposures of 1,2-DCP and DCM revealed a stronger liver carcinogenic potential compared to single exposure to 1,2-DCP. In addition, it was suggested that as a mechanism of tumor development, a variety of signaling pathways are activated by increased expression of cell proliferation-related factors.
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| Free Research Field |
実験病理学
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