The effects of exercise therapy on the recovery of memory function in internal capsule stroke model rats

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350599
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kawasaki Medical School
• Principal Investigator: HIMI Naoyuki 川崎医科大学, 医学部, 講師 (70412161)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Hisashi 川崎医療福祉大学, 医療技術学部, 講師 (30612981) ; KOGA Tomoshige 川崎医療福祉大学, 医療技術学部, 教授 (50186649)
• Research Collaborator: SHIROMOTO Takashi ; LU Feng ; MARUYAMA Emi (NAKAMURA Emi)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳梗塞 / リハビリテーション

Outline of Final Research Achievements

The new internal capsule (IC) stroke model using the optic fiber has been reported by other group in 2014. Therefore we have switched from optic fiber method to microsphere (MS) injection model showing memory dysfunction and IC stroke model-like motor dysfunction. Rats were forced to run on a treadmill with mild strength for 7 days as the exercise (Ex group). At the 8th day after beginning the exercise, MS were injected. Non-exercise group (NE group) and sham operated groups were also examined as control groups. The Morris water maze test were performed at 8 days after onset stroke. The memory functions in the Ex group was significantly improved compared with the NE group. However, in the severer MS model (increased number of particles), exercise showed no significant motor functional recovery.

Free Research Field

神経科学