2016 Fiscal Year Final Research Report
Multi-dimensional interactome analyses of patient derived cancer xenograft model for personalized medicine system
| Project/Area Number |
26430097
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Jichi Medical University (2016)
Central Institute for Experimental Animals (2014-2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | がん患者由来ゼノグラフト / 疾患モデル / NOGマウス / インタラクトーム |
|---|
| Outline of Final Research Achievements |
In this study, we performed the interactome analyses of Patient-derived xenografts (PDX) linked with clinical information. It disclosed cancer-stroma interactions associated with molecular target drug efficiencies comprehensively. High interactions were confirmed by in-vivo drug sensitivity tests or clinical effectiveness of molecular target drugs. Efficient establishment procedures of PDX were also statistically confirmed among from our results. We also established PDXs from malignant pleural effusion. The PDXs from malignant pleural effusion are efficient and valuable as same as from surgical specimen. It is possible to establish serial PDXs of the same patient less-invasively. Our results appear to be reliable for clinical simulations of chemotherapy and will definitely assist in the selection of the most sensitive anti-cancer drug for each patient. The fast and efficient establishment of individual PDXs will contribute to personalized anti-cancer therapies.
|
| Free Research Field |
動物実験モデル
|
