Role of DOCK family proteins in malignant transformation by human oncogenic Rac

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kyushu University
• Principal Investigator: Uruno Takehito 九州大学, 生体防御医学研究所, 准教授 (80532093)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: がん / 浸潤・転移 / 阻害剤 / Rac / Ras / DOCK1

Outline of Final Research Achievements

Oncogenic mutations in the small G proteins Rac and Ras are frequently found in a variety of human cancers. In this study, we found that genetic ablation of the Rac specific guanine nucleotide exchange factor DOCK1 or its pharmacological inhibition by its selective inhibitor TBOPP suppressed the survival and invasion of Rac/Ras-driven cancer cells. Moreover, the growth and invasion of these cancer cells transplanted in mice were effectively suppressed by treatment with TBOPP. Thus, DOCK1 plays critical roles in malignant transformation by oncogenic Rac and Ras, and may be a good therapeutic target for Rac/Ras-driven cancers.

Free Research Field

生物化学