2016 Fiscal Year Final Research Report
Analysis of the mechanism of anti-oxidative and anti-inflammatory actions of D-allose
| Project/Area Number |
26460123
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | D-allose / rare sugar / anti-oxidant / MAPK |
|---|
| Outline of Final Research Achievements |
D-allose, one of rare sugars, has anti-oxidative action, and is expected to have action to carbohydrate and lipid metabolism. By metabolome analysis, we found a total reducing potential increased significantly in cells and tissues. We also found that D-allose enhanced TXNIP (Thioredoxin Interacting Protein) expression. TXNIP expression and its phosphorylation were regulated by MAPK signaling system. By autoradiographic analysis of D-allose, we found that D-allose goes through blood brain barrier, and that D-allose is safe as a food material. We therefore could established the foundation of application of D-allose.
|
| Free Research Field |
細胞生理学
|
