Relationship between serum EETs concentrations and cardiovascular events in patients taking angiotensin II receptor blockers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460229
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Hokkaido Pharmaceutical University School of Pharmacy
• Principal Investigator: Toda Takaki 北海道薬科大学, 薬学部, 教授 (00254706)
• Research Collaborator: YAMASHITA Miki
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: エポキシエイコサトリエン酸類 / アンジオテンシンII受容体拮抗薬 / エイコサノイド類 / 相互作用 / アラキドン酸

Outline of Final Research Achievements

We investigated the influence of angiotensin II receptor blockers (ARBs) on the serum concentrations of eicosanoids (epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids, which are arachidonic acid metabolites) in patients. Multivariate analysis showed that eGFR (estimated GFR) was negatively associated with the serum levels of eicosanoids, and ARBs significantly decreased the levels. In addition, the serum levels of eicosanoids were significantly decreased in hypertensive patients regardless of whether they were taking ARBs.

Free Research Field

臨床薬理学、薬物動態学