2016 Fiscal Year Final Research Report
Amplification of intracellular signaling initiated near the plasma membrane transporters
| Project/Area Number |
26460312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Osaka Medical College (2016)
National Cardiovascular Center Research Institute (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Jin Meihua 国立循環器病研究センター, 肺高血圧症先端医学研究部, 研究員 (40746773)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 心筋リモデリング / 細胞内シグナル伝達 / Ca2+結合蛋白質 / 心肥大 / 低酸素刺激 / ノックアウトマウス |
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| Outline of Final Research Achievements |
Many problems have emerged at the beginning of study, and we changed the direction of study related to NHE1. We proceeded the study successfully for the most part. (1) A beta-blocker were found to have a potential for improvement of the disease in a Tg mouse of NHE1 which causes a heart failure. (2) In vitro study using cultured cells revealed that NHE1-binding protein CHP3 negatively regulates cardiomyocyte hypertrophy via inhibition of GSK3beta. (3) Analysis of CHP3 knockout mice revealed that CHP3 negatively regulates cardiac hypertrophy caused by a chronic hypoxia by regulating the expression level of CHP3.
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| Free Research Field |
分子細胞生理学
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