2016 Fiscal Year Final Research Report
Cancer stem cell targeting by fatty acid signals
| Project/Area Number |
26460424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nara Medical University |
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Principal Investigator |
Ohmori Hitoshi 奈良県立医科大学, 医学部, 研究員 (80213875)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | エライジン酸 / リノール酸 / がん幹細胞 / マイクロRNA |
|---|
| Outline of Final Research Achievements |
Effect of fatty acids is studied on mechanism of cancer stem activation, influence to cancer metastasis and chemoresistance. Elaidic acid, a trans fatty acid, showed high potential promoting cancer metastasis by activating cancer stem cells by 1) transactivation of EGFR and the subsequent wnt activation, and 2) inhibition of expression of pro-differentiation genes by micro RNAs. Linoleic acid, an ω-6 long chain fatty acid, induced gene expression of dormant-stem-associated factors and enhanced survival of cancer stem cells against chemotherapy.
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| Free Research Field |
分子病理
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