Acquisition strategy of tumor-specific markers using established micropapillary pattern pulmonary adenocarcinoma cell line

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kitasato University
• Principal Investigator: Sato Yuichi 北里大学, 医療衛生学部, 教授 (30178793)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 微乳頭肺腺癌 / 樹立細胞株 / 二次元電気泳動 / 自己抗体 / セクレトーム解析 / 可移植性腫瘍 / iPS細胞

Outline of Final Research Achievements

The factors conferring the increased malignancy on lung adenocarcinoma with micropapillary component (MPPAC) remain to be elucidated. I established cell line named as a KU-MPPAC derived from the micropapillary pattern adenocarcinoma of the lung. I investigate the property of this cell line in detail, and aimed at the acquisition of novel biomarkers for MPPAC using by the several proteomic techniques. We describe the characteristics of this cell line and obtained biomarker candidate proteins for MPPAC.

Free Research Field

医歯薬学