Stress response of cancer cells focusing the sphingolipid metabolism and its modulation by food ingredients

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460674
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Chubu University (2015-2016); Nagoya University (2014)
• Principal Investigator: MURATE Takashi 中部大学, 生命健康科学部, 教授 (30239537)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Sphingolipid metabolism / Cancer cell / Stress response / Food ingredient / Phytochemical / Anti-cancer action

Outline of Final Research Achievements

We have published 9 papers corresponding to the main title of the grant No. 26460674 between 2013 and 2016. Among them, ６ papers described the stress responses and the sphingolipid metabolism of cancer cells, whereas 2 papers analyzed the anti-cancer drug resistance of malignant cells. One paper elucidated the molecular mechanism of anti-cancer function of resveratrol, a food ingredient.
Based on these works, we concluded that malignant cells utilize heterogeneous mechanisms including aberrant sphingolipid metabolism, changes of DNA repair system, microtubules dynamics, mRNA half-life, and chromatin remodeling. As far as the sphingolipid metabolism was concerned, our data strongly supported the validity of the sphingolipid rheostat model telling that the balance between ceramide and sphingosine 1-phospahte determined cells' fate such as cell growth, survival, motion and differentiation.

Free Research Field

腫瘍学ならびにスフィンゴ脂質代謝解析