Investigation of the role of mucosal inductive immune system via indigenous bactria and dietary antigens

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460969
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: Iijima Hideki 大阪大学, 医学系研究科, 准教授 (90444520)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 炎症性腸疾患 / パイエル板 / 粘膜免疫誘導組織 / 腸内細菌

Outline of Final Research Achievements

Ulceration of the small intestine is induced when mice were intraperitoneally injected with indomethacine. We found chemokine receptor CCR7-deficient mice show worsening of the ulcer area in the small intestine. In addition, the population of CD103-positive dendritic cells which have a role for the induction of regulatory T cells was decreased in CCR7-deficient mice.
In contrast, ulcer area was significantly decreased in the wild-type mice orally administered nutritional therapy containing RNA and other nutrients (Impact(R)) or elementary diet with amino-acids. In mice treated with Impact showed significantly increased CD103-positive dendritic cells. These results indicate the importance of CD103-positive dendritic cells and immune-nutritional therapy and they can be effective to regulate mucosal immunity-associated intestinal inflammation.

Free Research Field

消化器内科学（炎症性腸疾患）