Macrophage specific delivery of TNF-a inhibits NASH liver injury.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460992
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: University of Toyama
• Principal Investigator: Takahara Terumi 富山大学, 大学院医学薬学研究部(医学), 准教授 (60240777)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 非アルコール性脂肪肝炎 / マクロファージ / ドラッグデリバリー

Outline of Final Research Achievements

Macrophages play important roles in liver injury and fibrosis during the progression of non-alcoholic steatohepatitis (NASH). In this study we try to establish effective delivery system into macrophages, and elucidate whether TNF-α siRNA complexed with schizophyllan (TNFα-SPG) inhibit liver inflammation and fibrosis in murine NASH models. We confirmed siRNA complexed with SPG can be specifically delivered into macrophage. In addition, TNFα-SPG successfully ameliorate inflammation, fibrosis, apoptosis, and ROS production in murine NASH model. Our result demonstrated a possible new therapeutic approach on macrophages by administration of siRNA-SPG for treatment of NASH.

Free Research Field

消化器病学