Molecular imaging of disease activity in pulmonary arterial hypertension

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kurume University
• Principal Investigator: Tahara Nobuhiro 久留米大学, 医学部, 准教授 (10320186)
• Co-Investigator(Renkei-kenkyūsha): HONDA AKIHIRO 久留米大学, 医学部, 助教 (90624510) ; KAIDA HAYATO 近畿大学, 医学部, 講師 (40299425) ; UENO TAKAFUMI 久留米大学, 医学部, 助教 (60599819)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺高血圧症 / FDG-PET/CT / 肺血管障害 / 右心負荷

Outline of Final Research Achievements

We investigated lung parenchymal and myocardial glucose metabolism in patients with pulmonary arterial hypertension (PAH) by FDG-PET/CT. FDG activity in the lung parenchyma and right ventricle (R)/left ventricle (L) was measured by maximum standardized uptake values (SUV). The lung parenchymal SUV and SUVR/L values were significantly higher than non-PAH subjects, reflecting pulmonary vasculopathy and right ventricular workload, respectively. Pulmonary vasodilators significantly decreased SUVR/L values and NT-pro-BNP, but not lung parenchymal SUV values, concomitantly with improvement of pulmonary hemodynamics and RVEF. In multiple stepwise regression analysis, RVEF, mPAP and NT-proBNP were independently associated with SUVR/L. The change in RVEF was a sole and independent determinant with that in SUVR/L after treatment. The lung parenchymal SUV and SUVR/L values are associated with disease severity of PAH.

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