2016 Fiscal Year Final Research Report
Molecular pathogenesis mechanism of idiopatic ventricular fibrillation related to Semapolin 3A gene
| Project/Area Number |
26461130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | セマフォリン3A / 特発性心室細動 / 一塩基多型 / ブルガダ症候群 |
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| Outline of Final Research Achievements |
We reported that Semapholin 3A (SEMA3A) was related to occurrence of ideoventricular ventricular fibrillation (IVF). The other SNPs having an interaction with SEMA3AI334V and likely to develop VF have not found in SEMA3A tag SNP and causative genes in Brugada syndrome. There was no difference in receptor binding assay and dimer formation between SEMA3I334V and wild type. We have to continue to consider relationship between SEMA3A and pathogenesis of arrhythmia.
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| Free Research Field |
循環器内科
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