Elucidation of molecular mechanism of survivin in inflammatory lung disease and development of new gene therapy method

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461203
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nippon Medical School
• Principal Investigator: Terasaki Mika 日本医科大学, 医学部, 助教 (50372785)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: サバイビン / 間質性肺炎 / 再生

Outline of Final Research Achievements

Survivin is a protein having two roles of cell proliferation and apoptosis inhibiting function, and focused on the pathology of interstitial pneumonia and analyzed the mechanism of action of this factor. In human and model mice of interstitial pneumonia disease, high expression of survivin was observed mainly in the regenerating alveolar epithelium. Even in cultured cells, similar expression increase was observed by induction of injury, and suppression of survivin remarkably inhibited cell proliferation. Since survivin expression is observed in the regenerating epithelium in various injuries regardless of the cause, it became clear that survivin is indispensable for regeneration upon cell injury.

Free Research Field

病理学