2016 Fiscal Year Final Research Report
Zinc effect for iron efflux from the neuronal cells
Project/Area Number |
26461291
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
|
Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 鉄 / 亜鉛 / フェロポルチン / セルロプラスミン / トランスフェリン / 亜鉛トランスポーター / マンガン |
Outline of Final Research Achievements |
Zinc can play an important role in the stability of ferroportin and ferrous iron binding to transferrin. We found that zinc transporter ZnT10 is localized to the plasma membrane and functional in Mn metabolism by effluxing cytosolic Mn. Because zinc has antioxidant activity, treatment with zinc may be useful in patients with neurodegeneration with brain iron accumulation to diminish iron accumulation in the brain.
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Free Research Field |
神経内科学
|