Development of imaging technique to preclinically diagnose Alzheimer's disease using clnical MRI

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: Tetsuya Yoneda 熊本大学, 大学院生命科学研究部(保), 准教授 (20305022)
• Co-Investigator(Kenkyū-buntansha): 平井 俊範 宮崎大学, 医学部, 教授 (40274724) ; 橋本 衛 熊本大学, 大学院生命科学研究部(医), 准教授 (20452881) ; 池田 学 大阪大学, 医学系研究科, 教授 (60284395)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: MRI / 認知症 / 位相画像 / アミロイド

Outline of Final Research Achievements

The aim of this study was to develop imaging technique to quantitatively detect amyloid plaque as a cause of Alzheimer's disease and preclinically diagnose Alzheimer's disease by using clinical MRI. This study used phase information of MRI for detecting amyloid plaque so as to quantitatively detect it on any clinical MRI. We concluded that phase information might quantitatively detect amyloid plaque with 3D multi-echo GRE sequence and subtraction between phase signal of super frontal gyrus and one of the other gyrus might be correlated with MMES score.

Free Research Field

磁気共鳴画像学