2016 Fiscal Year Final Research Report
Fundamental analysis of ischemic brain plasticity induced by bone marrow mesenchymal stem cell transplantation
| Project/Area Number |
26462214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Suzuki Junpei 札幌医科大学, 医学部, 研究員 (00572596)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 脳梗塞 |
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| Outline of Final Research Achievements |
Intravenous infusion of mesenchymal stem cells (MSCs) from adult bone marrow ameliorates functional deficits in rat cerebral infarction models. In this study, we found functional improvements evaluated with behavioral testing following systemic administration of MSCs in stroke. Immunohistochemical analysis demonstrated that synaptogenesis was induced around the ischemic lesion in the MSC treated group. Collectively, neural plasticity might contribute to the functional recovery following intravenous infusion of MSCs in a rat model of stroke.
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| Free Research Field |
脳神経外科、再生医学
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