2016 Fiscal Year Final Research Report
Role of NKT cells on eosinochilic chronic rhinosinusitis
| Project/Area Number |
26462575
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Hokkaido University |
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Principal Investigator |
Takagi Dai 北海道大学, 大学病院, 講師 (60374427)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 好酸球性副鼻腔炎 / HDAC活性 |
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| Outline of Final Research Achievements |
To analize the role of NKT cells and HDAC activity on eosinophilic chronic rhinosinusitis, we collected PBMC form patients. We investigated HDAC activity using HDAC activity kit, and found that HDAC activity was significantly decreased in patients of eosinophilic chronic rhinosinusitis. Furthermore, we investigated eosinophilic chronic rhinosinusitis patients before and after surgery, and found that Blood eosinophil count was significantly reduced after surgery in the eosinophilic chronic rhinosinusitis group. We also found that serum IL-5 tended to be reduced after surgery in eosinophilic chronic rhinosinusitis patients.
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| Free Research Field |
耳鼻咽喉科学
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