Roles of calcium-independent phospholipase A2 in neutrophil cytotoxicity

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Aiboshi Junichi 東京医科歯科大学, 医学部附属病院, 講師 (50256913)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ホスホリパーゼA2 / カルシウム非依存性ホスホリパーゼA2 / 好中球 / 急性炎症

Outline of Final Research Achievements

Phospholipase A2 (PLA2) consists of secretory PLA2 (sPLA2), cytosolic PLA2 (cPLA2), and calcium independent PLA2 (iPLA2). Compared to sPLA2 and cPLA2, roles of the iPLA2 enzyme in acute inflammation remain ill defined. Our current studies have demonstrated that iPLA2γ may be involved in multiple neutrophil cytotoxic functions (extracellular superoxide production, degranulation, chemotaxis, adhesion, adhesion molecule surface expression) as well as the leukocyte-endothelial cell interaction in rat mesenteric microcirculation. Thus the iPLA2γ enzyme may be essential for acute inflammatory process. In addition, iPLA2γ-associated metabolites other than arachidonic acid are likely to be signaling molecules of neutrophil cytotoxicity.

Free Research Field

医歯薬学