KLF-dependent cell differentiation- and EMT-inducing factor and suppression of oral carcinoma progression

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462859
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: The Nippon Dental University
• Principal Investigator: Imai Kazushi 日本歯科大学, 生命歯学部, 教授 (10328859)
• Co-Investigator(Kenkyū-buntansha): 須藤 遙 日本歯科大学, 生命歯学部, 講師 (20372980) ; 千葉 忠成 日本歯科大学, 生命歯学部, 准教授 (60350138)
• Co-Investigator(Renkei-kenkyūsha): MIHARA Nozomi 日本歯科大学, 生命歯学部, 助教 (00803264)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 口腔癌 / KLF / プロモーター

Outline of Final Research Achievements

Kruppel-like factor (KLF) plays a critical role in epithelial tissue development and homeostasis. Expression balance of KLF4 and KLF5 is considered to regulate carcinoma cell phenotypes and carcinoma progression. However, very little is known about a role KLF4/5 in oral carcinomas.
This study demonstrated that KLF4/5 regulate differentiation and dedifferentiation of oral carcinoma cells and that expression of KLF4 are suppressed by hypermethylation of the gene promoter. In regard to KLF5 expression, a region from +145 to +330 act as a minimal essential region and Sp3 binding to GC box was a indispensable event.

Free Research Field

口腔生化学